Endocrine Abstracts

Objective: To assess if adding slow-release liothyronine (SR-T3) to levothyroxine (l-T4) reduces persistent hypothyroid symptoms and signs on replacement with l-T4 alone.Design: Open label, two-period cross-over, cohort comparison. The main outcomes were changes in the serum T3 concentration and residual clinical hypothyroid indicants. Each study period was 10 weeks. The sample size required was d...

Objective: Report of hypothyroidism due to primary hypotriiodothyronaemia caused by a deficiency in peripheral generation.Design: Case report and computer modelling.Main outcome: A 28-year-old woman presented with hypothyroid symptoms and delayed ankle reflex relaxation times. She was not on any medications. The average thyroid stimulating hormone (TSH) concentrations was 2.5 (N: 3.8–5.5 mU/l), free thyroxine (T4) 12.3 ...